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研究業績

Chen, Z.*, Omori, Y.*, Koren, S., Shirokiya, T., Kuroda, T., Miyamoto, A., Wada, H., Fujiyama, A., Toyoda, A., Zhang, S., Wolfsberg, T.G., Kawakami, K., Phillippy, A.M., Mullikin, J.C., and Burgess, S.M. (2018) De Novo assembly of the goldfish (Carassius auratus) genome and the evolution of genes after whole genome duplication. , Science Advances 2019. 5(6):eaav0547.*equally contributed

Ueno A*, Omori Y*, Sugita Y, Watanabe S, Chaya T, Kozuka T, Kon T, Yoshida S, Matsushita K, Kuwahara R, Kajimura N, Okada Y, Furukawa T.Lrit1, a Retinal Transmembrane Protein, Regulates Selective Synapse Formation in Cone Photoreceptor Cells and Visual Acuity. Cell Rep. 2018 Mar 27;22(13):3548-3561. *equally contributed

Omori Y, Kubo S, Kon T, Furuhashi M, Narita H, Kominami T, Ueno A, Tsutsumi R, Chaya T, Yamamoto H, Suetake I, Ueno S, Koseki H, Nakagawa A, Furukawa T, Samd7 is a cell type-specific PRC1 component essential for establishing retinal rod photoreceptor identity, Proc Natl Acad. Sci. USA 2017 114(39):E8264-E8273

Okamoto S, Chaya T, Omori Y, Kuwahara R, Kubo S, Sakaguchi H, Furukawa T, Ick ciliary kinase is essential for planar cell polarity formation in inner ear hair cells and hearing function J Neurosci 2017, 37(8):2073-2085

Boubakri M, Chaya T, Hirata H, Kajimura N, Kuwahara R, Ueno A, Malicki J, Furukawa T, Omori Y.*  Loss of ift122, a Retrograde IFT Complex Component, Leads to Slow, Progressive Photoreceptor Degeneration Due to Inefficient Opsin Transport J Biol Chem. 2016 ;291 (47):24465-24474 *corresponding author

Omori Y, Chaya T, Yoshida S, Irie S, Tsujii T, Furukawa T Identification of G protein-coupled receptors (GPCRs) in primary cilia and their possible involvement in body weight control, PLoS One 2015, 10(6):e0128422.

Mizuhashi K, Omori Y, Furukawa T, Obif, a transmembrane protein, is required for bone mineralization and spermatogenesis in mice, PLoS One 2015, 10(7):e0133704.

Omori Y, Kitamura T, Yoshida S, Kuwahara R, Chaya T, Irie S, Furukawa T, Mef2d is essential for the maturation and integrity of retinal photoreceptor and bipolar cells. Genes to cells 2015 20(5):408-426.

Chaya T, Omori Y, Kuwahara R, Furukawa T, ICK is essential for cell type-specific ciliogenesis and the regulation of ciliary transport. EMBO J 2014;33(11):1227-1242

Mizuhashi K, Kanamoto T, Moriishi T, Muranishi Y, Miyazaki T, Terada K, Omori Y, Ito M, Komori T, Furukawa T, Filamin-interacting proteins, Cfm1 and Cfm2, are essential for the formation of cartilaginous skeletal elements. Human Molecular Genetics 2014, 23(11):2953-2967

Yamazaki D, Funato Y, Miura J, Sato S, Toyosawa S, Furutani K, Kurachi Y, Omori Y, Furukawa T, Tsuda T, Kuwabata S, Mizukami S, Kikuchi K, Miki H. Basolateral Mg2+ Extrusion via CNNM4 Mediates Transcellular Mg2+ Transport across Epithelia: A Mouse Model PLoS Genetics 2013, 9(12):e1003983

Omori Y, Araki1 F, Chaya T, Kajimura N, Irie S, Terada K, Muranishi Y, Tsujii T, Ueno S, Koyasu T, Tamaki Y, Kondo M, Amano S, Furukawa T, Presynaptic dystroglycan-pikachurin complex regulates the proper synaptic connection between retinal photoreceptor and bipolar cells J Neurosci 2012; 32(18):6126-6137

Zhao C, Omori Y, Brodowska K, Kovach P, Malicki J. Kinesin-2 family in vertebrate ciliogenesis. Proc Natl Acad Sci U S A. 2012 109(7):2388-93

Mizuhashi K , Kanamoto T, Ito M, Moriishi T, Muranishi Y, Omori Y, Terada K, Tsujii T, Tani A, Komori T, Furukawa T, OBIF, an osteoblast induction factor, plays an essential role for bone formation in association with reduced osteoblastogenesis. Development, Growth and Differentiation, 2012 54(4):474-480

Omori Y, Katoh K, Sato S, Muranishi Y, Chaya T, Onishi A, Minami T, Fujikado T, Furukawa T. Analysis of transcriptional regulatory pathways of photoreceptor genes by expression profiling of the Otx2-deficient retina. PLoS One 2011 6(5):e19685 

Omori Y, Chaya T, Katoh K, Kajimura N, Sato S, Muraoka K, Ueno S, Koyasu T, Kondo M, Furukawa T.  Negative regulation of ciliary length by ciliary male germ cell-associated kinase (Mak) is required for retinal photoreceptor survival. Proc Natl Acad Sci U S A. 2010, 107(52):22671-6. 

Kanagawa M, Omori Y, Sato S, Kobayashi K, Miyagoe-Suzuki Y, Takeda S, Endo T, Furukawa T, Toda T.  Post-translational maturation of dystroglycan is necessary for pikachurin binding and ribbon synaptic localization. J Biol Chem. 2010, 285(41):31208-16

Katoh K, Omori Y, Onishi A, Sato S, Kondo M, Furukawa T. Blimp1 suppresses Chx10 expression in differentiating retinal photoreceptor precursors to ensure proper photoreceptor development. J Neurosci 2010, 30 (19) 6515-6526

Sanuki R, Omori Y, Koike C, Sato S, Furukawa T. Panky, a novel photoreceptor-specific ankyrin repeat protein, is a transcriptional cofactor that suppresses CRX-regulated photoreceptor genes. FEBS letter 2010;584 (4):753-8.

Sato S, Omori Y, Katoh K, Kondo M, Kanagawa M, Miyata M, Funabiki K,Koyasu T, Kajimura N, Miyoshi T, Sawai H, Kobayashi K, Tani A, Toda T, Usukura J, Tano Y, Fujikado T and Furukawa T, Pikachurin, a dystroglycan ligand, is essential for photoreceptor ribbon synapse formation. Nature Neuroscience 2008, 11(8)923-931 

Omori Y, Zhao C, Saras A, Mukhopadhyay S, Kim W, Furukawa T, Sengupta P, Veraksa A, Malicki J. Elipsa is an early determinant of ciliogenesis that links the IFT particle to membrane-associated small GTPase Rab8. Nature Cell Biology. 2008 Apr;10(4):437-44.

Blachon S, Gopalakrishnan J, Omori Y, Polyanovsky A, Church A, Nicastro D, Malicki J, Avidor-Reiss T. Drosophila asterless and vertebrate Cep152 Are orthologs essential for centriole duplication. Genetics. 2008 Dec;180(4):2081-94.

Tsujikawa M, Omori Y, Biyanwila J, Malicki J. Mechanism of positioning the cell nucleus in vertebrate photoreceptors. Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14819-14824.

Okabe T, Ohmori Y, Tanigami A, Hishigaki H, Suzuki Y, Sugano S, Kawaguchi A, Nakaya H, Wakitani S. Detection of gene expression in synovium of patients with osteoarthritis using a random sequencing method. Acta Orthop. 2007 78(5):687-92. 

Omori Y, Malicki J. oko meduzy and related crumbs genes are determinants of apical cell features in the vertebrate embryo. Current Biology. 2006 16 (10):945-957.

Pujic Z, Omori Y, Tsujikawa M, Thisse B, Thisse C, Malicki J. Reverse genetic analysis of neurogenesis in the zebrafish retina. Dev Biol. 2006 293 (2): 330-347.

Ota T, Suzuki Y, Nishikawa T….., Ohmori Y, …., Nakamura Y, Ohara O, Isogai T, Sugano S. Complete sequencing and characterization of 21,243 full-length human cDNAs. Nature Genetics. 2004 36 (1) :40-45.

Adachi S, Jigami T, Yasui T, Nakano T, Ohwada S, Omori Y, Sugano S, Ohkawara B, Shibuya H, Nakamura T, Akiyama T. Role of a BCL9-related beta-catenin-binding protein, B9L, in tumorigenesis induced by aberrant activation of Wnt signaling. Cancer Res. 2004 64(23):8496-8501.

Shibui-Nihei A, Ohmori Y, Yoshida K, Imai J, Oosuga I, Iidaka M, Suzuki Y, Mizushima-Sugano J, Yoshitomo-Nakagawa K, Sugano S. The 5’ terminal oligopyrimidine tract of human elongation factor 1A-1 gene functions as a transcriptional initiator and produces a variable number of Us at the transcriptional level. Gene. 2003 ;311:137-45.

Omori Y, Imai J, Suzuki Y, Watanabe S, Tanigami A, Sugano S. OASIS is a transcriptional activator of CREB/ATF family with a transmembrane domain.Biochem Biophys Res Commun. 2002 293(1):470-477. 

Akiyama T, Gohda J, Shibata S, Nomura Y, Azuma S, Ohmori Y, Sugano S, Arai H, Yamamoto T, Inoue J. Mammalian homologue of E. coli Ras-like GTPase  Genes Cells. 2001 6(11):987-1001. 

Shibui A, Ohmori Y, Suzuki Y, Sasaki M, Nogami S, Sugano S, Watanabe J. Effects of DNA vaccine in murine malaria using a full-length cDNA library.Res Commun Mol Pathol Pharmacol. 2001 109(3-4):147-157.

Omori Y, Imai J, Watanabe M, Komatsu T, Suzuki Y, Kataoka K, Watanabe S, Tanigami A, Sugano S. CREB-H: a novel mammalian transcription factor belonging to the CREB/ATF family and functioning via the box-B element with a liver-specific expression. Nucleic Acids Res. 2001 29(10):2154-2162.

Omori Y, Tanigami A, Sugano S. Comparative PCR: a simple and sensitive method for quantifying low-abundance mRNA species. Genomics. 2000 67(2):140-145.

Omori Y, Suzuki M, Ozaki K, Harada Y, Nakamura Y, Takahashi E, Fujiwara T. Expression and chromosomal localization of KIAA0369, a putative kinase structurally related to Doublecortin. J
Hum Genet. 1998 43(3):169-177.

Shimada Y, Okuno S, Kawai A, Shinomiya H, Saito A, Suzuki M, Omori Y, Nishino N, Kanemoto N, Fujiwara T, Horie M, Takahashi E. Cloning and chromosomal mapping of a novel ABC transporter gene (hABC7), a candidate for X-linked sideroblastic anemia with spinocerebellar ataxia. J Hum Genet. 1998;43(2):115-22.

Omori Y, Kyushiki H, Takeda S, Suzuki M, Kawai A, Fujiwara T, Takahashi E, Nakamura Y. Cloning, expression and mapping of a novel human zinc-finger gene TCF17 homologous to rodent Kid1.Cytogenet Cell Genet. 1997 78(3-4):285-288.

Shimizu F, Watanabe TK, Okuno S, Omori Y, Fujiwara T, Takahashi E, Nakamura Y.Isolation of a novel human cDNA (rhoHP1) homologous to rho genes. Biochim Biophys Acta. 1997 1351(1-2):13-16 

Watanabe TK, Suzuki M, Omori Y, Hishigaki H, Horie M, Kanemoto N, Fujiwara T, Nakamura Y, Takahashi E. Cloning and characterization of a novel member of the human Mad gene family (MADH6). Genomics. 1997 42(3):446-451.


■総説・解説

茶屋太郎、大森義裕、古川貴久、「繊毛局在キナーゼICKは細胞種特異的な繊毛形成と繊毛内輸送の制御に必須である」実験医学 2014,10月号 32(16)2612-2615

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荒木章之、大森義裕、古川貴久「網膜視細胞シナプス形成に関わる細胞外マトリックスタンパク質ピカチュリン」日本薬理学雑誌 2009, 134(4), pp236

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大森義裕、 「膜結合型転写因子とアミロイド前駆体タンパク質のRipを介した転写制御」、化学と生物 2004, 42、5月号, 282-284

大森義裕 化学と生物 2004年、8月号pp537、9月号 pp584、10月号pp673、、11月号pp747、12月号, pp806、連載「初めての投稿論文1~5」

大森義裕、菅野純夫、 「完全長cDNAライブラリーの作製」腎と透析 増刊 分子腎臓病学、1998, 56-61



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