原著論文、総説(2005年以降)


Hatanaka Y, Tsusaka T, Shimizu N, Morita K, Suzuki T, Mochida S, Satoh M, Honda A, Hirose M, Kamimura S, Ogonuki N, Nakamura T, Nakano T, Kurumizaka H, Matsumoto K, Shinkai Y, Ogura A.
Histone H3 methylated arginine 17 is essential for reprogramming the paternal genome in zygotes.
Cell Rep., 20, 2756-2765, 2017

Furuta A, and Nakamura T.
DNA hypomethylation circuit of mouse rDNA repeats in the germ cell lineage.
Biochem. Biophys. Res. Commun., 490, 429-433, 2017

Tsuji A, Nakamura T, Shibata K.
Effects of mild and severe vitamin B1 deficiencies on the meiotic maturation of mice oocytes.
Nutrition and Metabolic Insights, 10, 1-9, 2017

Tsuji A, Noguchi R, Nakamura T, Shibata K.
Folic Acid Deficiency Does Not Adversely Affect Oocyte Meiosis in Mice.
J Nutr Sci Vitaminol, 62 (6), 375-379, 2016

Sekita Y, Nakamura T, Kimura T.
Reprogramming of germ cells into pluripotency.
World J. Stem Cells, 8 (8), 251-259, 2016

Okai S, Usui F, Yokota S, Hori-I Y, Hasegawa M, Nakamura T, Kurosawa M, Okada S, Yamamoto K, Nishiyama E, Mori H, Yamada T, Kurokawa K, Matsumoto S, Nanno M, Naito T, Watanabe Y, Kato T, Miyauchi E, Ohno H, Shinkura R.
High-affinity monoclonal IgA regulates gut microbiota and prevents colitis in mice.
Nature Microbiology, 1, 16103, 2016

Funaki S*, Nakamura T* (corresponding authors, *co-first authors), Nakatani T*, Umehara H, 
Nakashima H, Okumura M, Oboki K, Matsumoto K, Saito H, Nakano T.
Global DNA hypomethylation coupled to cellular transformation and metastatic ability.
FEBS lett., 589, 4053-4060, 2015

Matsuzaki H, Okamura E, Takahashi T, Ushiki A, Nakamura T, Nakano T, Hata K, Fukamizu A, Tanimoto K.
De novo DNA methylation through 5’-segment of the H19 ICR maintains its imprint during early embryogenesis.
Development, 142, 3833-3844, 2015

Arakawa T, Nakatani T, Oda M, Kimura Y, Sekita Y, Kimura T, Nakamura T, Nakano T.
Stella controls chromocenter formation through regulation of Daxx expression in 2-cell embryos.
Biochem. Biophys. Res. Commun., 466, 60-65, 2015

Kunoh T, Wang W, Kobayashi H, Matsuzaki D, Togo Y, Tokuyama M, Hosoi M, Koseki K, Wada S, Nagai N, Nakamura T, Nomura S, Hasegawa M, Sasaki R, Mizukami T.
Human Dynactin-Associated Protein Transforms NIH3T3 Cells to Generate Highly Vascularized Tumors with Weak Cell-Cell Interaction.
PLoS ONE, 10, e0135836, 2015 

Inoue K, Oikawa M, Kamimura S, Ogonuki N, Nakamura T, Nakano T, Abe K, Ogura A.
Trichostatin A specifically improves the aberrant expression of transcription factor genes in embryos produced by somatic cell nuclear transfer.
Scientific Rep, 5, 10127, 2015

Nakatani T, Yamagata K, Kimura T, Oda M, Nakashima H, Hori M, Sekita Y, Arakawa T, Nakamura T, Nakano T.
Stella preserves maternal chromosome integrity by inhibiting 5hmC-induced γH2AX accumulation
EMBO Rep., 16, 582-589, 2015

Xu X*, Smorag L*, Nakamura T* (*co-first authors), Kimura T, Dressel R, Fitzner A, Tan X, Linke M, Zechner U, Engel W , Pantakani K.
Dppa3 expression is critical for generation of fully-reprogrammed iPS cells and maintenance of Dlk1-Dio3 imprinting.
Nature Commun., 6, 6008, 2015

Nakamura T, Nakano T.

Stella and zygotic reprogramming.

In “Epigenetic Mechanisms in Cellular Reprogramming”Epigenetics and Human Health series, Meissner A and Walter J Eds., Springer, pp31-42, 2015

Tsuji A, Nakamura T, Shibata K. 

Biotin-deficient diet induces chromosome misalignment and spindle defects in mouse oocytes. 

Biosci. Biotechnol. Biochem., 79, 292-299, 2015
(Selected as cover article)


Funaki S*, Nakamura T* (corresponding author, *co-first authors), Nakatani T*, Umehara H*, Nakashima H, Nakano T.

Inhibition of maintenance DNA methylation by Stella.

Biochem. Biophys. Res. Commun., 453, 455-460, 2014

Shiromoto Y, Kuramochi-Miyagawa S, Daiba A, Chuma S, Katanaya A, Katsumata A, Nishimura K, Ohtaka M, Nakanishi M, Nakamura T, Yoshinaga K, Asada N, Nakamura S, Yasunaga T, Kojima-Kita K, Itou D, Kimura T, Nakano T. 

GPAT2, a Mitochondrial Outer Membrane Protein, in piRNA Biogenesis in Germline Stem Cells. 

RNA, 19,6, 803-810, 2013


Nakashima H, Kimura T, Kaga Y, Nakatani T, Seki Y, Nakamura T, Nakano T. 

Effects of Stella on DNA methylation dynamics during primordial germ cell development. 

Biol Reprod.,88, 5, 125, 1-9, 2013 

(Selected as cover article)


Nakamura T (corresponding author),
 Liu YJ, Nakashima H, Umehara H, Inoue K, Matoba S, Tachibana M, OguraA, ShinkaiY, Nakano T.

PGC7 binds histone H3K9me2 to protect against conversion of 5MeC to 5HmC in early embryos.

Nature, 486, 7403, 415-419, 2012


Liu YJ, Nakamura T (corresponding author), Nakano T.

Essential role of DPPA3 for chromatin condensation in mouse oocytogenesis.

Biol Reprod., 86, 2, 40, 1-8, 2012


Matoba S, Inoue K, Kohda T, Sugimoto M, Mizutani E, Ogonuki N, Nakamura T, Abe K, Nakano T, Ishino F, Ogura A.

RNAi-mediated knockdown of Xist can rescue the impaired postimplantation development of cloned mouse embryos. 

Proc Natl Acad Sci U S A., 108, 51, 20621-6, 2011


Wossidlo M, Nakamura T
, Lepikhov K, Marques CJ, Zakhartchenko V, Boiani M, Arand J, Nakano T, Reik W, Walter J.

5-Hydroxymethylcytosine in the mammalian zygote is linked with epigenetic reprogramming.

Nature Commun., 2, 241, 2011


Nakamura T
, Inoue K, Ogawa S, Umehara H, Ogonuki N, Miki H, Kimura T, Ogura A, Nakano T.

Effects of Akt signaling on nuclear reprogramming.

Genes Cells, 13, 1269-1277, 2008


Umehara H, Kimura T, Ohtsuka S, Nakamura T
, Kitajima K, Ikawa M, Okabe M, Niwa H, Nakano T.

Efficient derivation of embryonic stem cells by inhibition of Glycogen Synthase Kinase-3

Stem Cells, 25, 2705-2711, 2007 


Nakamura T
, Arai Y, Umehara H, Masuhara M, Kimura T, Taniguchi H, Sekimoto T, Ikawa M, Yoneda Y, Okabe M, Tanaka T, Shiota K, Nakano T.

PGC7/Stella protects against DNA demethylation in early embryogenesis.

Nature Cell Biol.,9, 1, 64-71, 2007


Kimura T, Nakamura T, Murayama K, Umehara H, Yamano N, Watanabe S, Taketo MM, Nakano T. 

The stabilization of b-catenin leads to impaired primordial germ cell development via aberrant cell cycle progression. 

Dev. Biol., 300, 545-553, 2006 


Nakamura T, Suzuki H, Wada Y, Kodama T, and Doi T. 

Fucoidan induces nitric oxide production via p38 mitogen-acrivated protein kinase and NF-kB-dependent signaling pathways through macrophage scavenger receptors. 

Biochem. Biophys. Res. Commun., 343, 286-294, 2006


Kimura T, Murayama K, Nakamura T, Watanabe S, Umehara H, Tomooka M, and Nakano T.  

Testicular teratomas: back to pluripotent stem cells. 

In “Developmental Biology of Neoplastic Growth”, Progress in Molecular and Subcellular Biology Series, Macieira-Coelho A. Eds., Elsevier, pp133-150, 2005

その他
バイオテクノロジー入門
高畑京也・蔡晃植・齊藤修 編著
今村綾・宇佐美昭二・尾山廣・数岡孝幸・河内浩行・佐々壽浩・髙村岳樹・田中直子・永井信夫・仲亀誠司・中村肇伸・徳田宏晴・殿山泰弘・濱田博喜・室伏誠・若生豊 共著
建帛社、2016年

中村肇伸
着床前胚と始原生殖細胞におけるDNAメチル化リプログラミング
生体の科学、vol. 66、no. 6、2015

中村 肇伸
母性因子を用いたiPS細胞の誘導効率と質の改善
細胞工学、vol. 34、no. 7、2015

中村 肇伸
DNAメチル化はヒトの初期胚で消去される
実験医学、vol. 32、no. 16、2014

中村 肇伸
受精後のエピジェネティック制御
細胞工学、vol. 33、no. 4、2014

中村 肇伸
PGC7はヒストンH3K9me2との結合を介して受精卵における5mCから5hmCへの変換を阻害する
細胞工学、vol. 31、no. 9、2012

中村 肇伸、仲野徹
母性因子PGC7はヒストンH3の9番目のリジン残基のジメチル化との結合を介し受精卵における5-メチルシトシンから5-ヒドロキシルメチルシトシンへの変換を阻害する
ライフサイエンス新着論文レビュー、5093、2012

中村 肇伸、仲野 徹
初期発生の重要イベントとエピジェネティック制御
再生医療、vol. 8、no. 4、2009

中村 肇伸、仲野 徹
受精卵におけるエピジェネティック不均等性の成立機構
蛋白質核酸酵素、vol. 52、no. 5、2007
 


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